The draw, which took place immediately after its Champions League counterpart in Egypt on Wednesday, also sees APR take on Seychelles topflight side Anse Réunion, while Al-Masry take on Green Buffaloes.
Africa Sports have been drawn against FC Nouadhibou and RS Berkane take on Mbour Petite-Côte, while Benni McCarthy’s Cape Town City must travel to Swaziland where they will play Young Buffaloes.
The games are scheduled to take place in February 2018, with the first leg coming between February 9-11 and the second leg set for a week later.
SuperSport United, Enyimba, USM Alger, Al-Hilal Al-Ubayyid, Motema Pembe, Al-Ahly Shendi, Nkana, Club Africain, Raja Casablanca and Zamalek have been drawn bye till the First round.
FIXTURES IN FULL
Petro de Luanda vs Masters Security Young Buffaloes vs Cape Town City Costa do Sol vs Jwaneng Galaxy TBD vs Hafia APR vs Anse Réunion Onze Créateurs vs ELWA United AFC Leopards vs Fosa Juniors Ngazi Club vs AS Port-Louis 2000 AS Mangasport vs AS Maniema Union Olympique Star vs Étoile Filante New Star vs Deportivo Niefang AS Tanda vs CS La Mancha Akwa United vs Banjul Hawks Al-Ittihad Tripoli vs Sahel US Ben Guerdane vs Al-Hilal Juba Asante Kotoko vs CARA Brazzaville Djoliba vs CR Belouizdad Al-Masry vs Green Buffaloes Simba vs Gendarmerie Nationale RS Berkane vs Mbour Petite-Côte Africa Sports vs FC Nouadhibou Zimamoto vs Welayta Dicha