Nurse also had six rebounds and three assists, while Natalie Achonwa chipped in with 13 points. Tamara Tatham added 10 for the victors.
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The University of Connecticut’s Breanna Stewart had a double-double of 17 points and 11 rebounds for record seven-time winners USA, who had led 23-13 after the first quarter.
But after levelling at halftime, Canada cleared away with a 26-point third quarter that set up its win. For USA, their last title came in 2007 and they will have to wait a little longer if they are to add an eighth crown.
Cuba claimed bronze with a 66-62 win over Brazil.
USA still tops the medal count with 169 — 65 gold — at this year’s Games, while Canada is second with 148.