The reigning champions will be considered favourites to progress to the knockout stage but will be presented with some difficult fixtures from the start of their run in the 2017-18 competition.
Real Madrid 4/1 to defend Champions League
Dortmund were quarter-finalists last season and while Spurs exited in the group stage, they went on to enjoy another impressive Premier League campaign.
Cypriot champions APOEL, meanwhile, will be regarded as major underdogs, having been eliminated in the play-off round by Copenhagen in 2016-17.
Matches will kick off on September 13, with the group concluding on December 6.
