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Cancer Genetics Cancer begins when one or more genes in a cell mutate (change from their normal form). This either creates an abnormal protein or no protein at all, both of which cause mutated cells to multiply uncontrollably. A large number of genes are being investigated for their role in melanoma, including inherited genes and genetic defects that are acquired due to environmental factors, such as excessive sun exposure. So far, specific genetic variations account for only 1% of all melanoma diagnoses, although a 2009 study of twins with melanoma showed that 55% of a person’s total melanoma risk may be due to genetic factors....

Alvarez (55-1-2, 37 KOs) will look to defend his super middleweight WBA, WBC and The Ring belts, while Saunders (30-0, 14 KOs) will put his WBO title on the line in at AT&T Stadium in Arlington, Texas. Alvarez claimed the WBA super middleweight title in December last year, defeating Callum Smith by unanimous decision, before defeating mandatory challenger Avni Yildirim in three rounds in February. Should the Mexican defeat Saunders on Saturday, he would move a step closer to becoming the first undisputed super middleweight champion in the four-belt era....

Unlike their previous two outings, which were marred by controversy, Canelo (58-2-2) made a statement from the outset of the third fight. He took the center of the ring and routinely beat Golovkin (42-2-1) to the punch. Maybe it was the added weight or the age, but the 40-year-old Golovkin just couldn’t get going after campaigning his entire career at 160 pounds. Golovkin outworked Canelo in each of their first two meetings, and plenty of observers believed that GGG deserved at least one win....

The inexplicable 118-110 scorecard of judge Adelaide Byrd certainly put a blemish on an otherwise spotless and highly competitive fight between two of the best boxers on the planet: It left fans old and new scratching their heads and rubbing their eyes. Sporting News scored the fight scored a draw, but there were plenty of winners — and losers — to come out of Las Vegas on Saturday. MORE: Brain-scrambling punches from Canelo vs....

Fresh off his unanimous decision (115-113, 115-113 and 116-112) win over Daniel Jacobs in Las Vegas on Saturday night, Alvarez was asked about the possibility of fighting Golovkin for a third time. Join DAZN and watch Golovkin vs. Steve Rolls on June 8 “I’m just looking for the biggest challenge,” Alvarez told DAZN. “That’s all I want, I want the biggest challenge and I want that to be my next fight....

Friday night, Erik Hahmann, the editor of Tampa Bay blog DRaysBay, did a public service by watching MLB Network and calling attention to Dan Plesac’s statement that Adam Jones is the current MVP of the American League. Upon receipt of a snarky reply about Mike Trout, with a nod to the song “Forgot About Dre,” Hahmann noted that Greg Amsinger picked Robinson Cano, on the grounds of where the Mariners might be without their second baseman....

NEWSWEEK: What’s the problem with the National Guard? Arnold Punaro: The Guard and Reserve forces were organized to be a strategic reserve, meaning to be used in the event of an all-out war with the Soviet Union. But now the Defense Department has declared the Guard and Reserve are “operational,” which means that though it’s a part-time force, some of it is in use at all times and the rest has to be ready to go at any time....

The focus now is on Condit and his secret life when it should be on Levy. If the media is going to render moral judgments, then the question should be posed: is it worse for him to be drawn to her for sex than for her to be drawn to him for power and status? He was not her supervisor; she was an intern for another government office, the federal Bureau of Prisons....

BIGGEST WINNERS George W. Bush has put to rest questions about his legitimacy as president, and his ability to do the job, erasing the Democrats’ best case against him. “Some things have changed permanently,” says Democratic pollster Mark Penn. “Bush will no longer be seen as potentially incompetent.” Rudy Giuliani exemplified leadership in a time of crisis, proving that a politician can have a messy private life and still exhibit strong character in his public life....

Ashcroft promises that the names of the women will be shielded. He says he needs their records to defend a legal challenge of the ban on the procedure known to its critics as partial birth abortion that President George W. Bush signed into law in November. But issuing government subpoenas to gain access to hospital records is unprecedented. A Chicago judge has already quashed one subpoena, and hospitals in New York and Philadelphia targeted by the Justice Department are weighing their response....

Having got his hands on the Premier League title last season, the experienced centre-half has embarked on a remarkable European adventure in 2016-17. Casillas claims Maldini record The reigning champions may have seen their crown slip domestically this term, but their fairytale run has continued in continental competition. Having eased their way through the group stage, Leicester’s reward in the last 16 was a meeting with Europa League specialists Sevilla....

BUY ‘EM Derek Jeter (19-for-63, 2 HR) and Jacoby Ellsbury (14-for-47, 4 2B, HR) have had success against David Price. Andrew McCutchen is 13-for-38 (.342) with a homer against Adam Wainwright. Freddie Freeman (6-for-11, HR) and Jason Heyward (6-for-15, HR) have enjoyed hitting against Zack Wheeler. Will Venable is 7-for-18 (.389) with a homer against Yovani Gallardo. SELL ‘EM Mark Trumbo (0-for-10, 3 K) and Miguel Montero (6-for-29, 11 K) have not hit Clayton Kershaw with any authority....

The kid he beat, a boy named Jared, clearly was not upset at the result. On Thursday, Jared reached out to Jones for a rematch. The ensuing conversation is rather hilarious. And finally, the piece de resistance: Cardale Jones: elite college football player, teacher of life lessons.

With two rounds of matches remaining before the Christmas break, Paris Saint-Germain, dubbed the champions-elect before a ball had even been kicked this season, find themselves four points off the pace of surprise leaders Nice. Sunday’s encounter against Lucien Favre’s side at the Parc des Princes was supposed to provide the platform from which PSG could cut the deficit, yet in the end it proved something of a damage limitation exercise as they secured a 2-2 draw having trailed by a couple at one stage....

Cardinals running back David Johnson did his best Marshawn Lynch impression against the Philadelphia defense on Sunday night. The former Northern Iowa star refused to go down on an incredible 47-yard touchdown run in the second quarter. MORE: Best of Week 15 | Odell Beckham Jr. won’t take responsibility for his actions Pile of bodies in Johnson’s path? No worries. He’ll just bounce it outside. Johnson finished the first half with 112 rushing yards and two touchdowns on 14 carries, but he is questionable to return with a right knee injury....

The Cardinals general manager said Wednesday that a 6-year-old boy named Kallin, a proud Eagles fan, said that Larry Fitzgerald would not be in Arizona this year. “I was glad to prove Kallin wrong,” Keim said before confirming that the Cardinals locked up the Pro Bowl receiver with a salary cap-friendly, two-year deal. According to NFL Network , Fitzgerald’s contract is worth $11 million annually and saves the team $13 million in cap space....

Will the situation improve in the coming months? NEWSWEEK’s Jennifer Barrett spoke with Tig Gilliam, CEO of Adecco Group North America, the largest employment staffing firm in the world, about the new data and what to expect for the rest of the year. Excerpts: NEWSWEEK: The latest report shows employers cut jobs again in April, but the losses were not as bad as some economists expected. Is there reason for optimism?...

"CarGo has played all three spots in the past and that's the plan right now, to move him over to center," general manager Bill Geivett said Wednesday. The Rockies traded Fowler to the Houston Astros on Tuesday for two unproven players, 23-year-old right-handed pitcher Jordan Lyles and 27-year-old outfielder Brandon Barnes. Geivett said the Rockies traded Fowler to get another young starting pitcher and to free up his $7.25 million salary for next season....

Bernstein, whose reporting with Woodward led to crucial disclosures in the 1970s Watergate scandal, which led former President Richard Nixon to resign, made the remarks during a Wednesday interview with CNN. Woodward’s book includes several taped interviews with Trump, in which the president admitted that he intentionally downplayed the coronavirus’s threat to the American people and that he understood it was more deadly than the common flu, despite suggesting the opposite in public....

MORE: Busch ‘sick and tired’ of Bristol | DiBenedetto cries after top-10 finish Edwards performed his trademark backflip after winning at Bristol Motor Speedway Sunday. But Edwards leaps from his car while standing in/on the driver’s-side window. Walters, who has performed stunts in such movies as “Captain America,” executed a blind backflip over a speeding racecar for a stunt orchestrated and filmed by Formula E. Fox Sports first posted video of the incredible feat, which was filmed at the Autodromo Hermanos Rodriguez racetrack in Mexico City with professional driver Alistair Whitton driving the car at 63 mph....